| 英文名稱 | Anti-PCNA Polyclonal Antibody |
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| 宿主 | Rabbit |
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| 別名 | ATLD2;cb16;Cyclin;HGCN872;MGC8367 |
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| 應(yīng)用 | WB |
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| 稀釋比例 | WB 1:500-2000. |
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| 交叉反應(yīng) | Human Mouse Rat |
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| 蛋白分子量 | 29kDa |
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| Gene ID | 5111 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
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| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | A synthetic peptide of human PCNA |
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| 性狀 | 液體 |
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| Public Immunogen Range | A synthetic peptide of human PCNA |
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| Subcellular Locations | Nucleus |
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| Swiss Prot | P12004 |
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| *類型 | Polyclonal Antibody |
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| 背景資料 | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. |
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