| 英文名稱 | Rabbit MAPK14 Polyclonal Antibody |
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| 應(yīng)用2 | WB IF |
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| 克隆類型2 | Polyclonal Antibody |
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| 別名 | CSBP;CSBP1;CSBP2;CSPB1;EXIP;Mxi2;PRKM14;PRKM15;RK;SAPK2A;p38;p38ALPHA
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| 應(yīng)用 | WB,IF |
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| 稀釋比例 | WB1:500-1:2000 IF1:50-1:200 |
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| 交叉反應(yīng) | Human Mouse |
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| 蛋白分子量 | 41kDa |
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| Gene ID | 1432 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲(chǔ)存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | Recombinant protein of human MAPK14 |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | Q16539 |
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| 克隆類型 | Polyclonal Antibody |
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| 來源 | Rabbit |
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| 背景資料 | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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